EXPERIMENTAL ANEMIA PRODUCED BY PHENYL-HYDRAZINE DERIVATIVES
نویسندگان
چکیده
منابع مشابه
P-85: Evaluation of Sperm Fertility Quality in Phenyl Hydrazine-Induced Hemolytic Anemia Impacts on Mice
Background: Anemia and consequently low oxygen can cause changes in the function and structure of the testis and spermatogenesis, Iron released from red blood cells, followed by the increased oxidative stress, which may cause tissue iron. This study was designed to minimize the deleterious effects of hypoxia on the genitals. Materials and Methods: Eighteen mature male mice were randomly divided...
متن کاملP-91: Phenyl Hydrazine-Induced Anemia-Related Hypoxia Effect on Mice Testes Parameters:Implication for Protective Effect of Crocin
Background: There are reports indicating that among the others, hypoxia is one of the testes threatening factors, which may occur intentionally or accidentally. Hypoxia could be created secondarily after some pathological conditions such as anemia. In this study we aimed to investigate the crocin protective effect on the testes parameters in the animals that were exposed against phenyl hydrazin...
متن کامل[1-Phenyl-2-(4-pyridyl)ethylidene]hydrazine
The title compound, C(13)H(13)N(3), is non-planar, with the pyridine and phenyl rings inclined at an angle of 80.7 (3)°. The central ethyl-idenehydrazine atoms lie in a plane [mean deviation = 0.013 (1) Å], which forms dihedral angles of 88.5 (1) and 9.4 (1)° with the pyridine and phenyl rings, respectively. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds...
متن کاملEnzymatic Activation of Hydrazine Derivatives
The oxidative metabolism of hydralazine, isoniazid, iproniazid, and phenylhydrazine has been studied using spin-trapping techniques. The oxidation of these hydrazine derivatives, catalyzed by horseradish peroxidase and prostaglandin synthetase, produces reactive free radical intermediates. Enzymatic activation of hydralazine produce the nitrogen-centered hydralazyl radical (RNHNH.); phenylhydra...
متن کاملFree radical-mediated activation of hydrazine derivatives.
Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1926
ISSN: 0021-9738
DOI: 10.1172/jci100049